An Antagonistically Pleiotropic Gene Regulates Vertebrate Growth, Maturity and Aging
Eitan Moses, Roman Franěk, Tehila Atlan, Henrik von Chrzanowski, Elizabeth Duxbury, Shay Kinreich, Alexei A. Maklakov, Itamar Harel
This study identifies vgll3 as an antagonistically pleiotropic gene in turquoise killifish, showing it accelerates growth and reproduction but increases late-life disease risk and mortality.
bioRxiv · May 1, 2023 · PreprintGenetics