Elizabeth Duxbury

Transgenerational pathogen defence extends beyond behavioural avoidance

The paper investigates transgenerational pathogen defense in five Caenorhabditis species, finding varied behavioral responses and survival benefits without behavioral avoidance.

Lifespan-extending downregulation of insulin signalling reduces germline mutation load

This study shows that reducing insulin signaling in adulthood extends lifespan and reduces germline mutations in C. elegans, but only when the HRDE-1 pathway is functional.

Evolutionary trade-offs between intergenerational and transgenerational fitness effects

The paper shows that beneficial intergenerational fitness effects in C. elegans can lead to detrimental transgenerational effects, demonstrating evolutionary trade-offs across generations.

An Antagonistically Pleiotropic Gene Regulates Vertebrate Growth, Maturity and Aging

This study identifies vgll3 as an antagonistically pleiotropic gene in turquoise killifish, showing it accelerates growth and reproduction but increases late-life disease risk and mortality.