Itamar Harel

The paper identifies molecular mechanisms that integrate environmental cues to trigger diapause exit in killifish embryos using transcriptomics and chemical screening.

This study models DDR syndromes in killifish and shows that cGAS-STING pathway activation contributes to disease phenotypes, with cGAS mutation partially rescuing defects.

This study profiles protein aggregation in seven tissues of aging killifish, revealing tissue-specific patterns linked to protein biophysics and quality control.

The paper identifies prion-like and phase-separated protein aggregates in aging vertebrate brains using quantitative proteomics in killifish and validates their propagation and functional properties.

This study shows that germline manipulation in killifish leads to sex-specific effects on longevity and repair mechanisms.

The paper introduces a high-throughput platform for functional studies of peptide hormones in fish, demonstrating its ability to rescue growth and fertility defects through genetic manipulation.

This study shows that mutating APRT in turquoise killifish extends male lifespan and improves metabolic health, with mitochondrial function and AMPK activity playing key roles.

This study identifies vgll3 as an antagonistically pleiotropic gene in turquoise killifish, showing it accelerates growth and reproduction but increases late-life disease risk and mortality.

This study analyzes epigenomic and transcriptomic changes across mouse tissues with age, identifying age-related immune pathway activation and retroviral sequence upregulation.