Single-sample, multi-omic mass spectrometry for investigating mechanisms of drug toxicity
Iqbal Mahmud, Waikin Chan, Karen E. Yannell, Cate Simmermaker, Genevieve C. Van de Bittner, Linfeng Wu, Daniel Chan, Sheher Banu Mohsin, Yiwei Liu, John Sausen, John N. Weinstein, Philip L. Lorenzi
The paper uses multi-omic mass spectrometry to analyze drug toxicity mechanisms in mice, identifying pathways involved in ASNase toxicity and proposing potential mitigation strategies.
bioRxiv · Feb 13, 2025 · PreprintCancer Biology