Iqbal Mahmud

This study shows that colorectal cancer in mice and rhesus macaques causes inflammatory neuropathy with calcium dysregulation and myelin issues, suggesting a causal link to chronic neurological problems in cancer survivors.

This paper identifies DH20931 as a first-in-class agonist of CerS2 that induces ER stress and apoptosis in TNBC cells, showing preclinical efficacy.

This study compares XCMS and MZmine 2 for peak picking in untargeted metabolomics and finds significant discrepancies in biomarker identification across different sample types and parameters.

The paper identifies ASX-173 as a potent ASNS inhibitor that enhances the anti-cancer effects of L-asparaginase in leukemia and shows its potential across multiple cancer types.

This study shows that loss of LATS1/2 in endothelial cells promotes a senescence-associated stemness (SAS) state, leading to atherothrombotic plaque formation through metabolic and mitochondrial dysregulation.

The paper uses multi-omic mass spectrometry to analyze drug toxicity mechanisms in mice, identifying pathways involved in ASNase toxicity and proposing potential mitigation strategies.

The paper tests imipridones in a mouse model of uveal melanoma, finding they reduce tumor growth and improve survival by targeting oxidative phosphorylation.

The paper introduces UFP-MS, a fast proteomics method, and applies it to study drug effects on mouse tissues, revealing tissue-specific metabolic changes.

This study identifies ROCK inhibition as a strategy to overcome metabolic adaptation in cancer cells to OXPHOS inhibition, showing synergistic anti-tumor effects.

TARO integrates microbiome and metabolomic data to identify cross-platform associations by leveraging phylogenetic tree structures and structured sparsity.