Waikin Chan

Mitochondrial defects and metabolic vulnerabilities in Lynch syndrome-associated MSH2-deficient endometrial cancer

This study identifies mitochondrial dysfunction and metabolic reprogramming in MSH2-deficient endometrial cancer, revealing a novel pathway and potential therapeutic targets.

Single-sample, multi-omic mass spectrometry for investigating mechanisms of drug toxicity

The paper uses multi-omic mass spectrometry to analyze drug toxicity mechanisms in mice, identifying pathways involved in ASNase toxicity and proposing potential mitigation strategies.

Ultra-Fast Multi-Organ Proteomics Unveils Tissue-Specific Mechanisms of Drug Efficacy and Toxicity

The paper introduces UFP-MS, a fast proteomics method, and applies it to study drug effects on mouse tissues, revealing tissue-specific metabolic changes.

Therapeutic modulation of ROCK overcomes metabolic adaptation of cancer cells to OXPHOS inhibition and drives synergistic anti-tumor activity

This study identifies ROCK inhibition as a strategy to overcome metabolic adaptation in cancer cells to OXPHOS inhibition, showing synergistic anti-tumor effects.