A humanized yeast model reveals dominant-negative properties of neuropathy-associated alanyl-tRNA synthetase mutations
Rebecca Meyer‐Schuman, Sheila Marte, Tyler J. Smith, Shawna M. E. Feely, Marina L. Kennerson, Garth A. Nicholson, Michael E. Shy, Kristin S. Koutmou, Anthony Antonellis
The paper demonstrates that neuropathy-associated AARS1 mutations exhibit dominant-negative effects by reducing yeast growth when co-expressed with wild-type AARS1.
Human Molecular Genetics · Apr 3, 2023Peer-reviewedGenetics