TAF1-gene editing impairs Purkinje cell morphology and function
Udaiyappan Janakiraman, Jie Yu, Aubin Moutal, Shelby N. Batchelor, Annadurai Anandhan, Rajesh Khanna, Mark A. Nelson
This paper develops a novel rat model for TAF1 ID syndrome using CRISPR-Cas9 and lentiviral transduction, showing Purkinje cell hypoplasia and behavioral deficits.
bioRxiv · Feb 9, 2019 · PreprintNeuroscience