Aubin Moutal

This study investigates how cholesterol modulates HCN channels in DRG neurons through sequential membrane remodeling, showing distinct effects in naive and neuropathic conditions.

This study shows FGFR3 autoantibodies cause small fiber neuropathy by directly affecting DRG neurons, suggesting they are pathogenic and therapeutic targets.

This study investigates how anti-CV2/CRMP5 autoantibodies cause pain in paraneoplastic neurological syndromes and identifies potential treatments.

This study identifies RhoA's role in modulating ordered membrane domains (OMDs) under stress, linking cytoskeletal changes to membrane mechanics and neuropathic pain.

This paper describes a non-viral CRISPR-Cas9 transfection method for editing primary human dorsal root ganglion neurons and confirms edits at genomic, protein, and functional levels.

The paper identifies a unique NaV1.7 domain that can be targeted to produce analgesia by disrupting its interaction with CRMP2.

The paper shows that female human nociceptors are sensitized by prolactin, indicating a female-selective pain mechanism.

This study shows that SARS-CoV-2 Spike protein blocks VEGF-A/NRP-1 signaling, reducing pain and potentially contributing to asymptomatic transmission.

This study shows that non-SUMOylated CRMP2 forms an endocytic complex to internalize NaV1.7 channels, and inhibiting this complex restores sodium currents in mice with neuropathic pain.

The paper identifies and validates small molecule and natural product inhibitors targeting the VEGF-A/NRP-1 interaction, with potential applications in treating neuropathic pain, cancer, and SARS-CoV-2 infection.

This study shows that preventing CRMP2 SUMOylation reduces mechanical allodynia in female neuropathic pain models but not in males or other pain types.

This study investigates how CRMP2 and CaV2.2 interactions in the prefrontal cortex influence cocaine-seeking behavior and relapse.

This paper develops a novel rat model for TAF1 ID syndrome using CRISPR-Cas9 and lentiviral transduction, showing Purkinje cell hypoplasia and behavioral deficits.

The paper identifies a novel CaV2.2 channel antagonist with broad antinociceptive effects and reduced side effects in pain models.

This study characterizes pain and sleep behaviors in a porcine model of NF1, identifying sex-dependent differences and potential therapeutic targets.

This study identifies a subpopulation of prelimbic cortex neurons that become hyperexcitable after chronic cocaine exposure, and shows that restoring Kv7 channel function reduces cue-induced cocaine seeking.