Jie Yu

The spatial and cell-type distribution of SARS-CoV-2 receptor ACE2 in human and mouse brain

This study maps the spatial and cell-type distribution of ACE2 in human and mouse brains using transcriptomic data, revealing potential targets for SARS-CoV-2 infection in the central nervous system.

Studies on CRMP2 SUMOylation-deficient transgenic mice identify sex-specific NaV1.7 regulation in the pathogenesis of chronic neuropathic pain

This study shows that preventing CRMP2 SUMOylation reduces mechanical allodynia in female neuropathic pain models but not in males or other pain types.

TAF1-gene editing impairs Purkinje cell morphology and function

This paper develops a novel rat model for TAF1 ID syndrome using CRISPR-Cas9 and lentiviral transduction, showing Purkinje cell hypoplasia and behavioral deficits.

Targeting the CaV - interaction yields a selective antagonist of the N-type CaV2.2 channel with broad antinociceptive efficacy

The paper identifies a novel CaV2.2 channel antagonist with broad antinociceptive effects and reduced side effects in pain models.