An aptamer-mediated base editing platform for simultaneous knock-in and multiple gene knockout for allogeneic CAR-T cells generation
Immacolata Porreca, Robert A. Blassberg, Jennifer A. Harbottle, Bronwyn C. Joubert, Olga Mielczarek, Jesse Stombaugh, Kevin Hemphill, Jonathan Sumner, Deividas Pazeraitis, Julia Liz Touza, Margherita Francescatto, Mike A. Firth, Tommaso Selmi, Juan Carlos Collantes, Žaklina Strezoska, , John J. Lambourne
This paper introduces a base editing platform for simultaneous gene knockout and transgene integration in T cells, showing higher efficiency and reduced chromosomal translocations compared to CRISPR-Cas9.
Molecular Therapy · Jun 26, 2024Peer-reviewedMolecular Biology