Impacted Spike Frequency Adaptation Associated with Reduction of KCNQ2/3 Promotes Seizure Activity in Temporal Lobe Epilepsy
Rongrong Li, Shicheng Jiang, Shuo Tan, Bei Liu, Yang Liu, Lei Jiang, Hong Ni, Qiyi Wang, Shidi Zhao, Hao Qian, Rongjing Ge
The paper identifies reduced KCNQ2/3 expression and impaired spike frequency adaptation in TLE patients and mouse models, showing their role in promoting seizure activity.
bioRxiv · Sep 25, 2020 · PreprintNeuroscience