Dynamic Compression of Spheroid-Laden Alginate Granular Composites Induces Hypertrophic Chondrocyte Phenotype
David H. Ramos‐Rodriguez, Andrea C. Filler, Sheetal R Palle, Shierly W. Fok, Erika E. Wheeler, Jonathan Kent Leach
This study shows dynamic compressive loading of MSC spheroids in alginate scaffolds with dECM promotes hypertrophic chondrocyte phenotype and bone formation through YAP1 activation.
bioRxiv · Mar 17, 2026 · PreprintBioengineering