Jonathan Kent Leach

Quantitative Head-to-Tail Analysis Reveals Heterogeneous Cellular Organization and Connexin Expression in the Porcine Sinoatrial Node

The paper quantifies cellular organization and connexin expression in the porcine sinoatrial node, revealing regional differences in pacemaking function and current source-sink relationships.

Bioorthogonal Tethering of FGF18 to Annealed Microgel Scaffolds Enhances Cartilage Repair

This paper develops FGF18-tethered microgel scaffolds to enhance cartilage repair by optimizing surface charge and growth factor presentation.

Dynamic Compression of Spheroid-Laden Alginate Granular Composites Induces Hypertrophic Chondrocyte Phenotype

This study shows dynamic compressive loading of MSC spheroids in alginate scaffolds with dECM promotes hypertrophic chondrocyte phenotype and bone formation through YAP1 activation.

Controlled delivery of immunomodulatory factors for mineralized tissue formation in an inflammatory microenvironment

This study shows that controlled delivery of immunomodulatory factors can enhance MSC osteogenesis and modulate inflammation in both in vitro and in vivo models of chronic inflammation.

Basigin Links Altered Skeletal Stem Cell Lineage Dynamics with Glucocorticoid-induced Bone Loss and Impaired Angiogenesis

This study identifies Basigin's role in GC-induced bone loss and impaired angiogenesis by linking altered skeletal stem cell dynamics to vascular dysfunction, showing that anti-Basigin therapy can reverse these effects.

Biofabrication of engineered tissues by 3D bioprinting of tissue specific high cell-density bioinks

This study develops tissue-specific high cell-density bioinks for 3D bioprinting, enabling the formation of multi-phase tissues with controlled architecture.