Author

Shieru Ishiyama

Yamagata University

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1

Signature Assays, Organisms & Methods

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Assay:cryo-EM· 1 Approach:experimental assay· 1 Research Focus:protein structure prediction· 1

Frequent Co-Authors

Atsushi Maejima· 1 shared Atsushi Tsugita· 1 shared Gatsogiannis Christos· 1 shared Ishin Nakahara· 1 shared Izumi Kumagai· 1 shared K. SatoiD· 1 shared Koki MakabeiD· 1 shared Mayuka Ishii· 1 shared

Activity by Year

2025-2025 · peak 1/yr

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10 top collaborators · 45 mutual co-author links

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1 shared paperBiochemistry

Atsushi Maejima

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1 paper

Recent·Most cited

Structural basis for bispecific antibody design: arrangement of domain linkage produces activity enhancement

K. Sato, Shiro Uehara, Atsushi Tsugita, Mayuka Ishii, Shieru Ishiyama, Atsushi Maejima, Ishin Nakahara, Misae Nazuka, Takashi Matsui, Gatsogiannis Christos, Takeshi Yokoyama, Izumi Kumagai, Koki Makabe, Ryutaro Asano, Yoshikazu Tanaka

This study determines the cryo-EM structures of two bispecific antibody types and shows that domain linkage rearrangement leads to activity enhancement by altering complex shape and dynamics.

Cell Reports · Jul 1, 2025Peer-reviewedBiochemistry