A transcriptional biosensor reveals mechanisms of α-ketoglutarate signaling to chromatin
Alex C. Sternisha, Haocheng Li, Kumar Gajendra, Yi Xiao, Xin Zhao, Jeffrey Isaac Traylor, Lei Guo, Ji Hyung Jun, Morgan Fleishman, Tracey Shipman, Vinesh T. Puliyappadamba, Pranita Kaphle, Qing Ouyang, Michael Schmidt, Diana D. Shi, , Samuel K. McBrayer
The paper develops a biosensor to monitor α-ketoglutarate in human cells and identifies a mitochondrial-to-nuclear pathway regulating chromatin methylation.
Science · Jul 16, 2026Peer-reviewedSynthetic Biology