Author

Alexander C.-Y. Tsai

Harvard University

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 1 Synthetic Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Research Focus:drug response / drug discovery· 1 Organism:mouse· 1 Assay:proteomics· 1

Frequent Co-Authors

Diana D. ShiiD· 2 shared John G. DoenchiD· 2 shared Kalil G. AbdullahiD· 2 shared Samuel K. McBrayeriD· 2 shared Vineshkumar Thidil PuliyappadambaiD· 2 shared Alex C. SternishaiD· 1 shared Chad A. BrautigamiD· 1 shared Christian GegeiD· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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2 shared papersSynthetic Biology

Diana D. ShiORCID

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Author profile →

2 papers

Recent·Most cited

A transcriptional biosensor reveals mechanisms of α-ketoglutarate signaling to chromatin

Alex C. Sternisha, Haocheng Li, Kumar Gajendra, Yi Xiao, Xin Zhao, Jeffrey Isaac Traylor, Lei Guo, Ji Hyung Jun, Morgan Fleishman, Tracey Shipman, Vinesh T. Puliyappadamba, Pranita Kaphle, Qing Ouyang, Michael Schmidt, Diana D. Shi, , Samuel K. McBrayer

The paper develops a biosensor to monitor α-ketoglutarate in human cells and identifies a mitochondrial-to-nuclear pathway regulating chromatin methylation.

Science · Jul 16, 2026Peer-reviewedSynthetic Biology

KDM6 Enzymes are the Mechanistic Targets of Mutant IDH that Dictate Replication Stress Sensitivity

Alexander C.-Y. Tsai, Mathew D. Lin, Vineshkumar Thidil Puliyappadamba, Dorothy M. Junginger, Victoria G. Donovan, Eleanor G. Kaplan, Laura M. Drepanos, Hiroaki Wakimoto, Daniel P. Cahill, Julie A. Losman, Kent William Mouw, Kalil G. Abdullah, John G. Doench, Duane Nash, Daniel Vitt, , Diana D. Shi

This study identifies KDM6 enzymes as targets of R2HG from mutant IDH, linking them to replication stress sensitivity in gliomas and introduces a DHODH inhibitor, GLIO-1, with potential clinical applications.

bioRxiv · Apr 17, 2026 · PreprintCancer Biology