Antibodies against the capsid induced after intracranial AAV administration limits second administration in a dose dependent manner
Y.-G. Xu, Xiaoni Bai, Jianhua Lin, Kang Lu, Shihan Weng, Yi‐Ying Wu, Shanggong Liu, Houlin Li, Zheng Wu, Gong Chen, Wen Li
This study shows that high-dose AAV injection in mice induces neutralizing antibodies that limit subsequent AAV infections, with B cells playing a key role.
Molecular Therapy — Methods & Clinical Development · Jan 25, 2025Peer-reviewedImmunology