Wen Li

This study shows that high-dose AAV injection in mice induces neutralizing antibodies that limit subsequent AAV infections, with B cells playing a key role.

This study investigates NEUROD1-induced astrocyte-to-neuron conversion using single-cell multiomics, revealing transcriptional and epigenetic changes and comparing it to ASCL1-induced conversion.

This study shows NeuroD1 gene therapy converts reactive astrocytes to neurons in adult NHP brains after stroke, increasing neuronal density and protecting interneurons.

The paper challenges a previous study on in vivo glia-to-neuron conversion by showing that high AAV doses cause artifacts and recommends safer dosages for reliable results.