IGF2BP3 amplifies antiviral innate immunity with implications for autoimmune diseases
Ao Zhang, Shijin Geng, Rong-Chun Tang, Hengxiang Yu, Yunxuan Zhou, Lan Zhang, Xiuyuan Sun, Jun Zhang
This paper identifies IGF2BP3 as a critical amplifier of antiviral innate immunity, showing it enhances viral RNA sensing and IFN-I production, and reveals its role in autoimmune diseases.
bioRxiv · Aug 6, 2026 · PreprintImmunology