Targeting EZH2 Oncogenic Splicing: Decoding the Regulatory Network and Antisense Correction
Md Rafikul Islam, Preeti Nagar, Naomi McNaughton, Shabiha Afroj Heeamoni, Md Mahbub Hasan, Shila Kandel, Israt Jahan Mukta, Panagiotis Tsakiroglou, William Brian Dalton, Omar Ibrahim Abdel-Wahab, Adrian R. Krainer, Mohammad Alinoor Rahman
This study identifies splicing dysregulation in SF-mutated cancers and demonstrates that antisense oligonucleotides can correct aberrant splicing and restore tumor suppressor function.
bioRxiv · Jan 8, 2026Cancer Biology