Author

William Brian Dalton

Johns Hopkins UniversityORCID 0000-0002-1314-0534Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 3 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Organism:human· 2 Research Focus:gene regulatory network inference· 1 Organism:mouse· 1

Frequent Co-Authors

Benjamin G. Dubner· 2 shared Gabriel GhiauriD· 2 shared Panagiotis TsakiroglouiD· 2 shared Adrian R. KraineriD· 1 shared Alexei M. BygraveiD· 1 shared Ben LangmeadiD· 1 shared Bogdan C. Paun· 1 shared Clayton P. SantiagoiD· 1 shared

Activity by Year

2022-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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2 shared papersCancer Biology

Benjamin G. Dubner

Mutual co-authors in cluster

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3 papers

Recent·Most cited

Cancer BiologyGenes & DevelopmentPeer-reviewedAug 3, 2026

Targeting EZH2 Oncogenic Splicing: Decoding the Regulatory Network and Antisense Correction

Md Rafikul Islam, Preeti Nagar, Naomi McNaughton…·Mohammad Alinoor Rahman

This study identifies splicing dysregulation in SF-mutated cancers and demonstrates that antisense oligonucleotides can correct aberrant splicing and restore tumor suppressor function.

2 citations

humanbulk RNA-seq

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Cancer BiologybioRxivPreprintMay 13, 2025

Serine auxotrophy is a targetable vulnerability driven by PSAT1 suppression in AML

Ilias Sinanidis, Panagiotis Tsakiroglou, Benjamin G. Dubner…·William Brian Dalton

The paper identifies serine auxotrophy in AML as a vulnerability driven by PSAT1 suppression, showing sensitivity to serine/glycine restriction and potential therapeutic targeting.

1 citation

humanbulk RNA-seq

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Molecular BiologyNature CommunicationsPeer-reviewedOct 1, 2022

Cell-specific regulation of gene expression using splicing-dependent frameshifting.

Jonathan P. Ling, Alexei M. Bygrave, Clayton P. Santiago…·Seth Blackshaw

This paper introduces SLED, a splicing-based method to control gene expression in specific cell types, demonstrating its utility in targeting neurons, photoreceptors, and cancer cells.

28 citationstop 5%

mousebulk RNA-seq

𝕏 PostBluesky