Mycothiazole enables structural characterization of entire ubiquinone-accessing tunnel in mitochondrial respiratory complex I
Shinsuke Akisada, Ryohei Otani, Takahiro Masuya, 秀嗣 都, Hiroki Saito, Kaoru Mitsuoka, Hideto Miyoshi, Ken Yokoyama, Masatoshi Murai
This study uses mycothiazole to stabilize and reveal the structure of the UQ-accessing tunnel in mitochondrial complex I, showing a hybrid conformational state.
bioRxiv · Oct 5, 2026 · PreprintBiochemistry