Author

Shiran Su

National Institutes of Health

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Neuroscience· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:mouse· 2 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

David L. BrodyiD· 2 shared Thomas J. EsparzaiD· 2 shared Caroline M. Francescutti· 1 shared Elvira Rodionova· 1 shared Joong Hee Kim· 1 shared

Activity by Year

2022-2023 · peak 1/yr

Co-Author Collaboration Network

5 top collaborators · 10 mutual co-author links

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2 shared papersNeuroscience

David L. BrodyORCID

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2 papers

Recent·Most cited

Enhanced in Vivo Blood Brain Barrier Transcytosis of Macromolecular Cargo Using an Engineered pH-sensitive Mouse Transferrin Receptor Binding Nanobody

Thomas J. Esparza, Shiran Su, Caroline M. Francescutti, Elvira Rodionova, Joong Hee Kim, David L. Brody

This paper develops a pH-sensitive nanobody to enhance blood brain barrier transcytosis of macromolecular cargo in mice, showing improved retention and distribution of engineered constructs.

bioRxiv · Apr 26, 2023 · PreprintNeuroscience

Selection of single domain anti-transferrin receptor antibodies for blood-brain barrier transcytosis using a neurotensin based assay and histological assessment of target engagement in a mouse model of Alzheimer's related amyloid-beta pathology

Shiran Su, Thomas J. Esparza, David L. Brody

The paper develops anti-mTfR VHHs for BBB transcytosis and evaluates their hypothermic effects and target engagement in a mouse model, finding no direct correlation between hypothermia and plaque labeling.

PLoS ONE · Oct 18, 2022Peer-reviewedNeuroscience