David L. Brody

Enhanced in Vivo Blood Brain Barrier Transcytosis of Macromolecular Cargo Using an Engineered pH-sensitive Mouse Transferrin Receptor Binding Nanobody

This paper develops a pH-sensitive nanobody to enhance blood brain barrier transcytosis of macromolecular cargo in mice, showing improved retention and distribution of engineered constructs.

Individualized precision targeting of dorsal attention and default mode networks with rTMS in traumatic brain injury-associated depression

This study identifies individualized rTMS targets for traumatic brain injury-associated depression using resting-state network mapping, showing improved connectivity after treatment.

Selection of single domain anti-transferrin receptor antibodies for blood-brain barrier transcytosis using a neurotensin based assay and histological assessment of target engagement in a mouse model of Alzheimer's related amyloid-beta pathology

The paper develops anti-mTfR VHHs for BBB transcytosis and evaluates their hypothermic effects and target engagement in a mouse model, finding no direct correlation between hypothermia and plaque labeling.

Astrogliosis mapping in individual brains using multidimensional MRI

This paper develops a machine learning framework to map astrogliosis in individual brains using multidimensional MRI, showing strong correlation with histological findings.

Multidimensional MRI for characterization of subtle axonal injury accelerated using an adaptive nonlocal multispectral filter

This paper evaluates a filter to reduce scan time in multidimensional MRI by improving noise reduction and accuracy of injury biomarker maps.

SEQUIN multiscale imaging of mammalian central synapses reveals loss of synaptic microconnectivity resulting from diffuse traumatic brain injury

This paper introduces SEQUIN, a super-resolution imaging workflow for analyzing synapses, and shows synapse loss in traumatic brain injury and Alzheimer's models.

rTMS with individualized resting-state network mapping for neuropsychiatric sequelae of repetitive traumatic brain injury in a retired NFL player

This paper applies individualized resting-state network mapping to guide rTMS treatment for treatment-resistant depression in a retired NFL player, showing clinical improvement.

Soluble amyloid-beta buffering by plaques in Alzheimer disease dementia versus high-pathology controls

The paper investigates whether amyloid-beta plaques sequester toxic soluble Aβ aggregates in Alzheimer disease dementia, finding no significant difference in Aβ binding between dementia and high-pathology control groups.