Thomas J. Esparza

Antibody Profiles in Pediatric Autoimmune Neuropsychiatric Disorders Associated with Streptococcal Infections

This study investigates antibody profiles in PANDAS patients and finds no significant differences in GAS-IgG levels between cases and controls, but identifies potential anti-neural autoantibodies in some patients.

Enhanced in Vivo Blood Brain Barrier Transcytosis of Macromolecular Cargo Using an Engineered pH-sensitive Mouse Transferrin Receptor Binding Nanobody

This paper develops a pH-sensitive nanobody to enhance blood brain barrier transcytosis of macromolecular cargo in mice, showing improved retention and distribution of engineered constructs.

Selection of single domain anti-transferrin receptor antibodies for blood-brain barrier transcytosis using a neurotensin based assay and histological assessment of target engagement in a mouse model of Alzheimer's related amyloid-beta pathology

The paper develops anti-mTfR VHHs for BBB transcytosis and evaluates their hypothermic effects and target engagement in a mouse model, finding no direct correlation between hypothermia and plaque labeling.

Soluble amyloid-beta buffering by plaques in Alzheimer disease dementia versus high-pathology controls

The paper investigates whether amyloid-beta plaques sequester toxic soluble Aβ aggregates in Alzheimer disease dementia, finding no significant difference in Aβ binding between dementia and high-pathology control groups.