Author

Shivashakthi Shivaraman

Lyon 1 Université

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Developmental Biology· 1 Pathology· 1

Signature Assays, Organisms & Methods

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Organism:zebrafish· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Approach:experimental assay· 1 Assay:scRNA-seq· 1 Approach:statistical model· 1

Frequent Co-Authors

Florence RuggieroiD· 2 shared Frédéric SohmiD· 2 shared Sandrine BretaudiD· 2 shared Adrien DucretiD· 1 shared Antonella ForlinoiD· 1 shared Bruno AllardiD· 1 shared Chloé Exbrayat-HeritieriD· 1 shared Christine BerthieriD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 35 mutual co-author links

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2 shared papersDevelopmental Biology

Florence RuggieroORCID

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2 papers

Recent·Most cited

Rewiring Fibroblast-Muscle Axis Drives Progressive Pathology in Bethlem Myopathy

Shivashakthi Shivaraman, Laurent Gilquin, Frédéric Sohm, Rawan Fareh, Laurence Legeai‐Mallet, Antonella Forlino, Emilie Dambroise, Sandrine Bretaud, Florence Ruggiero

This study identifies fibroblasts as key drivers of disease progression in Bethlem myopathy using a zebrafish model and single-nucleus RNA sequencing.

bioRxiv · May 18, 2026 · PreprintDevelopmental Biology

A zebrafish model of Bethlem myopathy reveals CaV1.1 as the missing link between collagen type VI deficiency and muscle dysfunction

Romane Idoux, Chloé Exbrayat-Heritier, Adrien Ducret, Shivashakthi Shivaraman, Marilyne Malbouyres, Francisco Jaque-Fernández, Christine Berthier, Frédéric Sohm, Vincent Jacquemond, Sandrine Bretaud, Florence Ruggiero, Bruno Allard

This study uses a zebrafish model of Bethlem myopathy to show that collagen VI deficiency disrupts CaV1.1 function, leading to increased sarcoplasmic reticulum Ca2+ leak and muscle dysfunction.

bioRxiv · Jun 2, 2025 · PreprintPathology