Transient interdomain interactions shape the conformational ensemble governing RNA recognition by the tandem RRMs of Sex-lethal
Julia Meyer, Kristian Schweimer, Paul Matzner, Shohei Yoshida, Andrea Lomoschitz, Sandra Augsten, Bernd Simon, Po‐Chia Chen, Janosch Hennig
This study shows that RNA recognition by the Sxl protein depends on a dynamic conformational ensemble rather than a single structure, and perturbing this balance impairs RNA binding.
bioRxiv · Aug 7, 2026 · PreprintBiophysics