The role of Nef in the long-term persistence of the replication-competent HIV reservoir in South African women
Sherazaan D. Ismail, Shorok Sebaa, Bianca Abrahams, Martha Nason, Mitchell J. Mumby, Jimmy Dimitrios Dikeakos, Sarah Joseph, Matthew Moeser, Ronald I. Swanstrom, Nigel Garrett, Carolyn E. Williamson, Thomas C. Quinn, Melissa-Rose Abrahams, Andrew D. Redd
This study investigates how HIV-1 Nef's ability to downregulate MHC-I affects the size of the replication-competent viral reservoir in South African women on ART, finding a significant association between MHC-I downregulation and reservoir size.
Journal of Virology · Jun 24, 2025Peer-reviewedPathology