Widespread discordance between mRNA expression, protein abundance and de novo lipogenesis activity in hepatocytes during the fed-starvation transition
Austin Landgraf, Junichi Okada, Maxwell Horton, Li Ping Liu, Shoshana Solomon, Yunping Qiu, Irwin J. Kurland, Simone Sidoli, Jeffrey E. Pessin, Kosaku Shinoda
The paper examines mRNA, protein, and lipogenesis activity in hepatocytes during feeding and starvation, finding widespread discordance between mRNA and protein levels, especially in sex-biased genes and lipogenic pathways.
bioRxiv · Apr 15, 2025 · PreprintBioinformatics