Author

Maxwell Horton

Albert Einstein College of Medicine

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Molecular Biology· 2 Bioinformatics· 1 Systems Biology· 1

Signature Assays, Organisms & Methods

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Organism:mouse· 4 Approach:statistical model· 4 Research Focus:differential expression· 3 Assay:bulk RNA-seq· 2 Approach:experimental assay· 2 Assay:proteomics· 2 Assay:scRNA-seq· 2 Research Focus:cell type annotation· 1

Frequent Co-Authors

Jeffrey E. PessiniD· 4 shared Austin Landgraf· 3 shared Irwin J. KurlandiD· 3 shared Junichi OkadaiD· 3 shared Kosaku ShinodaiD· 3 shared Li Ping LiuiD· 3 shared Simone SidoliiD· 3 shared YUNPING QIUiD· 3 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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4 shared papersMolecular Biology

Jeffrey E. PessinORCID

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4 papers

Recent·Most cited

Female-specific m6A remodeling in the liver correlates with post-transcriptional metabolic adaptation to high fat diet

Sofia V. Krylova, Maxwell Horton, G Bucciarelli, Li Liu, Jacob L. Berrigan, Ronald Cutler, Kartik Chandran, Nathaniel W. Snyder, Toma Tebaldi, Simone Sidoli, Kamini Singh, Jeffrey E. Pessin

The paper identifies female-specific m6A RNA methylation changes in mouse livers under high-fat diet that correlate with post-transcriptional metabolic adaptations and protein remodeling.

bioRxiv · Jun 22, 2026 · PreprintSystems Biology

A novel subset of hepatocytes is simultaneously gluconeogenic and de novo lipogenic in the fed state and is naturally insulin resistant

Junichi Okada, Austin Landgraf, Maxwell Horton, YUNPING QIU, Alus M. Xiaoli, Roberto A. Ribas, Li Ping Liu, Sofia V. Krylova, Hernando J. Olivos, Victor L. Schuster, Fajun Yang, Takeshi Saito, Ramon C. Sun, Meredith A. Hawkins, Gary J. Schwartz, , Jeffrey E. Pessin

bioRxiv · Mar 16, 2026 · PreprintMolecular Biology

Spatial hepatocyte plasticity of gluconeogenesis during the metabolic transitions between fed, fasted and starvation states

Junichi Okada, Austin Landgraf, Alus M. Xiaoli, Li Ping Liu, Maxwell Horton, Victor L. Schuster, Fajun Yang, Simone Sidoli, Yunping Qiu, Irwin J. Kurland, Carolina Eliscovich, Kosaku Shinoda, Jeffrey E. Pessin

The paper shows that gluconeogenic gene expression and activity in liver hepatocytes change spatially and temporally during feeding, fasting, and starvation states.

Nature Metabolism · Apr 25, 2025Peer-reviewedMolecular Biology

Widespread discordance between mRNA expression, protein abundance and de novo lipogenesis activity in hepatocytes during the fed-starvation transition

Austin Landgraf, Junichi Okada, Maxwell Horton, Li Ping Liu, Shoshana Solomon, Yunping Qiu, Irwin J. Kurland, Simone Sidoli, Jeffrey E. Pessin, Kosaku Shinoda

The paper examines mRNA, protein, and lipogenesis activity in hepatocytes during feeding and starvation, finding widespread discordance between mRNA and protein levels, especially in sex-biased genes and lipogenic pathways.

bioRxiv · Apr 15, 2025 · PreprintBioinformatics