Cryo-EM structures reveal the PP2A-B55α and Eya3 interaction that can be disrupted by a peptide inhibitor
Shasha Shi, Xueni Li, Christopher Alderman, Lars Wick, Wei Huang, North Foulon, Lingdi Zhang, John J. Rossi, Wenxin Hu, Shouqing Cui, Hongjin Zheng, Derek J. Taylor, Heide L. Ford, Rui Zhao
The paper determines cryo-EM structures of PP2A-B55 and Eya3 interaction, showing how a peptide inhibitor disrupts this interaction and affects Myc stability in TNBC.
Journal of Biological Chemistry · May 23, 2025Peer-reviewedMolecular Biology