Wei Huang

This paper develops multivalent nanobodies that neutralize multiple S. aureus toxins, showing potent activity in murine models of sepsis and pneumonia.

The paper investigates the cellular response to puromycin-induced translation stress and identifies ribosome dimerization mediated by rRNA expansion segments as a conserved stress response mechanism.

The paper determines cryo-EM structures of PP2A-B55 and Eya3 interaction, showing how a peptide inhibitor disrupts this interaction and affects Myc stability in TNBC.

This study identifies and engineers a UDP-rhamnosyltransferase from Trillium tschonoskii to enable heterologous biosynthesis of polyphyllin II in yeast.

The paper presents an integrated model of the vertebrate augmin complex using cryo-EM, structural prediction, and electron microscopy, revealing its structure, conservation, and microtubule binding site.

The paper reports cryo-EM structures of GLP-1R with ago-allosteric modulators, revealing their mechanism of action and providing insights for therapeutic design.