John J. Rossi

This study identifies a tRNA-derived small RNA that reduces cardiac fibrosis and hypertrophy through cell-type-specific mechanisms in mouse and human cardiac cells.

This paper develops a conditional-siRNA system that targets calcineurin in cardiac cells to reduce hypertrophy by responding to nppa mRNA, showing specific activation under stress conditions.

The paper determines cryo-EM structures of PP2A-B55 and Eya3 interaction, showing how a peptide inhibitor disrupts this interaction and affects Myc stability in TNBC.

The paper explores the use of inhalation-delivered RNA aptamers as a therapeutic approach against SARS-CoV-2.

This study examines how Dicer knockout affects RNA interference efficacy using different DsiRNA structures, finding that tetra-looped DsiRNAs show increased gene silencing in Dicer-expressing cells.