DOT1L primarily acts as a transcriptional repressor in hematopoietic progenitor cells
Shaon Borosha, Anamika Ratri, Sami M. Housami, Shubham Rai, Subhra Ghosh, Carrie A. Malcom, V. Praveen Chakravarthi, Jay L. Vivian, Timothy A. Fields, M. A. Karim Rumi, Patrick E. Fields
This study investigates the role of DOT1L in hematopoietic progenitor cells by analyzing transcriptomes of knockout and mutant models, revealing its function as a transcriptional repressor.
bioRxiv · Oct 15, 2020 · PreprintDevelopmental Biology