Age-associated spontaneous activation of BMP signaling inhibits the canonical Wnt pathway through ICAT to promote osteoarthritis
Bhupendra Kumar, Sayeda Fauzia Iqbal, Ankita Jena, Shuchi Arora, Saahiba Thaleshwari, Makoto Mark Taketo, Amitabha Bandyopadhyay
This study shows that age-related BMP signaling activation inhibits Wnt/{beta}-catenin through ICAT, leading to osteoarthritis in mice.
bioRxiv · Oct 2, 2024 · PreprintPathology