Makoto Mark Taketo

The paper shows how coordinated Wnt and Hedgehog signaling creates sharp cell-type boundaries by synchronizing cell-cycle exit and differentiation.

This study shows Wnt signaling regulates NG2 glia fate in adult mouse cortex, promoting neuronal conversion while impairing oligodendrocyte maturation after ischemic injury.

The paper shows that tumors drive the accumulation of GATA3-dependent effector tissue Tregs through TCR-dependent oligoclonal expansion, promoting tumor growth.

The paper shows that coordinated timing between Wnt and Hedgehog signaling generates sharp cell-type boundaries during hair follicle development.

This study shows that age-related BMP signaling activation inhibits Wnt/{beta}-catenin through ICAT, leading to osteoarthritis in mice.

This study shows that stabilizing β-catenin in mammary epithelium impairs branching morphogenesis and promotes epidermal differentiation over hair follicle fate.

This study shows that constitutive activation of canonical Wnt signaling disrupts choroid plexus epithelial identity in mice and human stem cell-derived organoids.

This study shows that canonical Wnt/{beta}-catenin signaling modulates the timing and progression of dendritic growth in adult-born hippocampal neurons, with distinct effects in young and aged mice.

This study shows that canonical Wnt signaling regulates patterning, differentiation, and nucleogenesis in mouse hypothalamus and prethalamus, with defects observed in both gain and loss of function mutations.