Shuhao Zhang

High-throughput physics-based enzyme engineering

This paper introduces a physics-based framework for enzyme engineering that combines machine learning and molecular mechanics to predict catalytic rates and selectivity with high accuracy.

Structural basis of endogenous inverse agonism and subtype selectivity at melanocortin receptors

The paper reports cryo-EM structures of melanocortin receptors bound to endogenous inverse agonists, revealing mechanisms of inverse agonism and subtype selectivity.