Xiaoguang Lei

High-throughput physics-based enzyme engineering

This paper introduces a physics-based framework for enzyme engineering that combines machine learning and molecular mechanics to predict catalytic rates and selectivity with high accuracy.

Pseudopaline-mediated zinc uptake by Pseudomonas aeruginosa determines specific clinically relevant phenotypes and infection outcome

This study shows that pseudopaline-mediated zinc uptake in Pseudomonas aeruginosa enables clinically relevant phenotypes and influences infection outcomes.

MRGPRX4 is a novel bile acid receptor in cholestatic itch

The paper identifies MRGPRX4 as a novel bile acid receptor involved in cholestatic itch, showing its activation by bile acids and its role in itch induction in humans.