Remodelling of chromatin architecture and super-enhancer landscape in lamin A/C depleted HGSOC
Shreyasi Dey Sarkar, Poulami Goswami, Amrutayani Panda, Vishnu S. Mishra, Bhabani Shankar Mohanty, Roli Budhwar, Kakoli Bose, Shuvojit Paul, Ayan Banerjee, Pradip Chaudhari, Kaushik Sengupta
This study investigates the effects of lamin A/C depletion on chromatin organization in HGSOC, finding detethering of gene-poor chromatin, compartment switching, and rewiring of super-enhancers, leading to reduced proliferation.
bioRxiv · Sep 10, 2026 · PreprintCancer Biology