RGC-specific reversal of lipid peroxidation drives neuroprotection and vision restoration in optic nerve ischemia by targeting GPX4
Ming Yang, Jie Pan, Shweta Modgil, Rishita Rama Pujari, Chenjie Pan, Anas Alkhabaz, Xiaobai Ren, Liping Liu, Ali Shariati, Tazbir Ahmed, Hugo Wu, Roopa Dalal, Yaping Joyce Liao
This study identifies lipid peroxidation as a driver of neurodegeneration in NAION and shows that GPX4 overexpression protects RGCs and restores vision.
bioRxiv · Aug 29, 2026 · PreprintNeuroscience