Author

Roopa Dalal

Stanford UniversityORCID 0000-0002-7150-8093Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Organism:mouse· 4 Research Focus:drug response / drug discovery· 3 Research Focus:cell type annotation· 2 Organism:rat· 2 Research Focus:benchmarking· 1 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Haoliang HuangiD· 3 shared Liang LiiD· 3 shared Yang HuiD· 3 shared Andrew ShiniD· 2 shared Daniel PalankeriD· 2 shared Davis Pham-HowardiD· 2 shared Fang Fang· 2 shared Liang LiuiD· 2 shared

Activity by Year

2019-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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3 shared papersNeuroscience

Haoliang HuangORCID

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Author profile →

6 papers

Recent·Most cited

Biomimetic scaffolds mimic human subretinal debris for preclinical testing of prosthetic vision

Mohajeet B. Bhuckory, Vladimir Mamchik, Keith Ly, Nathan Jensen, Viktoryia I. Shautsova, Quentin Devaud, Andrew Shin, Davis Pham-Howard, Roopa Dalal, Ludwig Galambos, Theodore I Kamins, Daniel Palanker

This paper develops biomimetic scaffolds to mimic human subretinal debris in animal models, improving the accuracy of preclinical testing for subretinal prostheses.

bioRxiv · Oct 7, 2026 · PreprintBioengineering

RGC-specific reversal of lipid peroxidation drives neuroprotection and vision restoration in optic nerve ischemia by targeting GPX4

Ming Yang, Jie Pan, Shweta Modgil, Rishita Rama Pujari, Chenjie Pan, Anas Alkhabaz, Xiaobai Ren, Liping Liu, Ali Shariati, Tazbir Ahmed, Hugo Wu, Roopa Dalal, Yaping Joyce Liao

This study identifies lipid peroxidation as a driver of neurodegeneration in NAION and shows that GPX4 overexpression protects RGCs and restores vision.

bioRxiv · Aug 29, 2026 · PreprintNeuroscience

GPX4 Promotes Optic Nerve Regeneration and RGC Neuroprotection

Ming Yang, Fuyun Bian, Xue Feng, Liang Li, Haoliang Huang, Liang Liu, Roopa Dalal, Hang Yang, Pranav Varma Suraparaju, Frank Cao, Petrina Ong, Alexandria Luo, Dong Liu, Yang Hu

This study shows that GPX4 overexpression in RGCs promotes optic nerve regeneration and neuroprotection in glaucoma models.

bioRxiv · Jun 3, 2025 · PreprintNeuroscience

Enhancing Prosthetic Vision by Upgrade of a Subretinal Photovoltaic Implant in situ

Mohajeet B. Bhuckory, Nicharee Monkongpitukkul, Andrew Shin, Anna Kochnev Goldstein, Nathan Jensen, Sarthak Vinay Shah, Davis Pham-Howard, Emma Butt, Roopa Dalal, Ludwig Galambos, Keith Mathieson, Theodore I Kamins, Daniel Palanker

This study upgrades a subretinal photovoltaic implant in rats, improving visual acuity from 100m to 28m pixels.

Nature Communications · Mar 21, 2025Peer-reviewedNeuroscience

Silicone Oil-Induced Glaucomatous Neurodegeneration in Rhesus Macaques

Ala Moshiri, Fang Fang, Pei Zhuang, Haoliang Huang, Xue Feng, Liang Li, Roopa Dalal, Yang Hu

This paper establishes a rhesus macaque model of glaucomatous neurodegeneration using silicone oil injection, showing RGC death, optic nerve degeneration, and functional deficits similar to human glaucoma.

International Journal of Molecular Sciences · Dec 14, 2022Peer-reviewedNeuroscience

Silicone oil-induced ocular hypertension in mouse models glaucomatous neurodegeneration and neuroprotection

Jie Zhang, Liang Li, Haoliang Huang, Fang Fang, Hannah C. Webber, Pei Zhuang, Liang Liu, Roopa Dalal, Peter H. Tang, Vinit B. Mahajan, Yang Sun, Shaohua Li, Mingchang Zhang, Jeffrey Louis Goldberg, Yang Hu

This paper develops a reversible mouse model of secondary glaucoma using silicone oil and validates it for testing neuroprotective therapies.

eLife · May 15, 2019Peer-reviewedNeuroscience