Jie Pan

RGC-specific reversal of lipid peroxidation drives neuroprotection and vision restoration in optic nerve ischemia by targeting GPX4

This study identifies lipid peroxidation as a driver of neurodegeneration in NAION and shows that GPX4 overexpression protects RGCs and restores vision.

Molecular Signatures of Resilience to Alzheimer's Disease in Neocortical Layer 4 Neurons

The paper identifies molecular signatures of resilience in neocortical layer 4 neurons in Alzheimer's disease using single-cell and spatial transcriptomics.

FCGRT, a cancer-derived immunoglobulin G binding protein, mediates the malignant phenotype of glioma

This study identifies FCGRT as a prognostic factor in glioma, showing its role in promoting tumor proliferation and invasion through interaction with CIgG.

Single-soma transcriptomics of tangle-bearing neurons in Alzheimer's disease reveals the signatures of tau-associated synaptic dysfunction

The paper identifies gene expression signatures in Alzheimer's disease neurons with tau aggregates, revealing shared and subtype-specific molecular changes related to synaptic function and metabolism.

CircTulp4 functions in Alzheimer's disease pathogenesis by regulating its parental gene, Tulp4

The paper identifies circTulp4 as a circRNA that regulates its parental gene Tulp4, affecting nervous system function and potentially contributing to Alzheimer's disease pathogenesis.