Aβ-42 sidechain deamidation at Q15 or N27 modulates protein aggregation and alters microglial cytokines and CD68
Martin N. Griffin, Daniel M. Dinakarapandian, Chenxing Li, Pranay Ramaswamy, Sia J. Saheba, Janie Lee, Tarunya Rao Sudarshan, Maria Sajimon, Christopher J. Wheeler, Jevgenij A. Raskatov, Anant K. Paravastu, Levi Benjamin Wood
This study investigates how deamidation at Q15 or N27 in Aβ-42 affects its aggregation and microglial immune response, finding reduced inflammation and altered CD68 expression.
ACS Chemical Neuroscience · Sep 5, 2026Peer-reviewedNeuroscience