Stimulating microglial neuroinflammation with amyloid-beta oligomers compatible with solid-state NMR structural characterization
Daniel M. Dinakarapandian, Tarunya Rao Sudarshan, Martin N. Griffin, Pranay Ramaswamy, Phuong H Nguyen, Tzu-Ying Chiu, Chenxing Li, S. Shirin Kamalaldinezabadi, Jens O. Watzlawik, Terrone L. Rosenberry, Scott M. Stagg, Zhexing Wen, Levi Benjamin Wood, Anant K. Paravastu
This paper develops a detergent-free method to produce Aβ42 oligomers compatible with solid-state NMR and shows they induce stronger microglial inflammation than monomers.
bioRxiv · Oct 20, 2026 · PreprintNeuroscience