Levi Benjamin Wood

Stimulating microglial neuroinflammation with amyloid-beta oligomers compatible with solid-state NMR structural characterization

This paper develops a detergent-free method to produce Aβ42 oligomers compatible with solid-state NMR and shows they induce stronger microglial inflammation than monomers.

Aβ-42 sidechain deamidation at Q15 or N27 modulates protein aggregation and alters microglial cytokines and CD68

This study investigates how deamidation at Q15 or N27 in Aβ-42 affects its aggregation and microglial immune response, finding reduced inflammation and altered CD68 expression.

Transcriptomic Profiling of High vs. Low Flow Regions of Mouse and Human Trabecular Meshwork

The paper compares transcriptomic differences between high and low flow regions in mouse and human trabecular meshwork to understand intraocular pressure regulation.

Mitochondrially Transcribed dsRNA Mediates Manganese-induced Neuroinflammation

This paper identifies a novel mechanism by which manganese disrupts mitochondrial transcriptome processing, leading to dsRNA accumulation and neuroinflammation through MDA5 activation.

Neuroinflammatory Stress Preferentially Impacts Synaptic MAPK Signaling and Mitochondria in Excitatory Neurons

This study identifies synaptic proteome changes in response to neuroinflammation, revealing mitochondrial and MAPK signaling disruptions in excitatory neurons linked to Alzheimer's disease.

Neuronal p38α knockout protects against neurological consequences following repetitive mild traumatic brain injury

This study shows neuronal p38α knockout reduces neurological and immune consequences of repetitive mild traumatic brain injury in a sex-dependent manner.

L-DOPA treatment promotes sustained neurovascular and synaptichomeostasis in the diabetic retina

This study shows L-DOPA treatment sustains neurovascular and synaptic function in diabetic retinas, with effects lasting after treatment ends.

Identification of novel Kv1.3 channel-interacting proteins using proximity labelling in T-cells

The paper identifies novel Kv1.3 channel-interacting proteins in T-cells using proximity labeling, revealing interactions with immune signaling and trafficking machinery, and links some interactors to autoimmunity risk.

A Feature Learning Model Identifies Predictive Attributes of Mesenchymal Stromal Cell Efficacy

A feature learning model identifies cytokine profiles and signaling pathways predictive of mesenchymal stromal cell therapeutic efficacy in a rat osteoarthritis model.

Brain Mecp2 Gene Dosage and Gene Therapy Shape Multi-Omic Signatures and Putative Biomarkers in Rett Syndrome

The paper identifies cross-species biomarkers and mechanisms in Rett Syndrome using gene therapy and multi-omic analysis in mice.

YAP regulates periosteal expansion in fracture repair

This study identifies YAP and TAZ as regulators of periosteal expansion during fracture repair, showing their role in cell proliferation and BMP4 regulation.

Sensory neurostimulation promotes stress resilience with frequency-specificity

This study shows that AV flicker at specific frequencies can mitigate stress-induced changes in mice, with 10Hz effective in males and 40Hz in females.

Inhibition of p38 MAPK after repetitive mild TBI ameliorates immune signaling and behavioral deficits

This study investigates the effects of p38 MAPK inhibition on immune signaling and behavioral deficits after repetitive mild TBI in mice, finding sex-dependent benefits in inflammation and functional outcomes.

Aberrant Fibro-Adipogenic Progenitor Subpopulations Drive Volumetric Muscle Loss-Induced Fibrosis

This study identifies an aberrant FAP subpopulation in VML that drives fibrosis and presents potential targets for scarless muscle regeneration.

Adaptive protein synthesis in genetic models of copper deficiency and childhood neurodegeneration

The paper investigates how neuronal cells adapt to copper deficiency by increasing protein synthesis through mTORC1 activation and reduced PERK signaling in multiple model systems.

Microglia Morphological Response to Mesenchymal Stromal Cell Extracellular Vesicles Demonstrates EV Therapeutic Potential for Modulating Neuroinflammation

This paper demonstrates that MSC-EVs modulate microglia morphology and cytokine secretion, suggesting their therapeutic potential for neuroinflammation, and introduces a high-throughput morphological screening method for EV bioactivity.

Delivery of A Jagged1-PEG-MAL hydrogel with Pediatric Human Bone Cells Regenerates Critically-Sized Craniofacial Bone Defects

This study investigates JAG1 delivery with pediatric human osteoblasts as a bone regenerative therapy for craniofacial defects in a murine model.

Plasma Proteomic Signature of Mucolipidosis Type IV

The paper identifies plasma proteomic signatures associated with MLIV, showing decreased neuronal proteins and increased muscle proteins, with specific markers correlating with disease severity.

Proximity labeling proteomics reveals Kv1.3 potassium channel immune interactors in microglia.

The paper identifies Kv1.3 potassium channel interactors in microglia using proximity labeling proteomics, revealing domain-specific interactions with immune signaling proteins during inflammation.

Frequency and duration of sensory flicker controls astrocyte and neuron specific transcriptional profiles in 5xFAD mice

The paper investigates how different frequencies and durations of sensory flicker affect transcriptional profiles in 5xFAD mice, showing frequency- and duration-specific changes in immune, neuronal, and metabolic genes.

Brain rhythms control microglial response and cytokine expression via NFkappaB signaling

This study shows that specific brain rhythms alter microglial morphology and cytokine expression through NFkappaB signaling, with frequency-specific effects observed in healthy animals.

Profiling the neuroimmune cascade in 3xTg mice exposed to successive mild traumatic brain injuries

This study examines how repeated mild traumatic brain injuries affect the brain in 3xTg mice, identifying sex-specific changes in gene expression and immune responses.

Native-state proteomics of Parvalbumin interneurons identifies novel molecular signatures and metabolic vulnerabilities to early Alzheimer's disease pathology

Cellular proteomic profiling using proximity labelling by TurboID-NES in microglial and neuronal cell lines.

The paper uses TurboID-NES to profile proteomes of microglial and neuronal cell lines, showing it captures a significant portion of the proteome and responds to LPS treatment.

Defective neuritogenesis in Abcd1/2 deficient rat neurons due to intrinsic and astrocyte-dependent mechanisms

This study identifies neurodevelopmental defects in X-ALD using rat models, showing intrinsic and astrocyte-dependent mechanisms affecting neuritogenesis.

Cell type-specific biotin labeling in vivo resolves regional neuronal proteomic differences in mouse brain

Microglial ERK signaling is a critical regulator of pro-inflammatory immune responses in Alzheimer’s disease

This study identifies ERK phosphorylation in microglia as a critical regulator of pro-inflammatory responses in Alzheimer’s disease using pre-clinical models and human proteomic data.

JAGGED1 Stimulates Cranial Neural Crest Cell Osteoblast Commitment Pathways and Bone Regeneration Independent of Canonical NOTCH Signaling

This study shows JAG1 promotes bone regeneration in mice by activating osteogenic pathways in cranial neural crest cells, independent of canonical NOTCH signaling.

Flow-cytometric microglial sorting coupled with quantitative proteomics identifies moesin as a highly-abundant microglial protein with relevance to Alzheimer's disease