The multimodal transcriptional response of denervated skeletal muscle involves alterations in cholesterol homeostasis impacting muscle size
Cristofer Calvo, Casey O. Swoboda, Fabián Montecino, Siddhant Nagar, Michael J. Petrany, Chengyi Sun, Hima Bindu Durumutla, Mattia Quattrocelli, Douglas P. Millay
This study identifies a multimodal transcriptional response in denervated skeletal muscle, revealing altered cholesterol homeostasis and its impact on myofiber size.
Proceedings of the National Academy of Sciences · Sep 23, 2025Peer-reviewedCell Biology