Douglas P. Millay

This study uses single nucleus RNA sequencing to identify altered angiogenic signaling in JDM muscle, highlighting vascular and IFN pathways.

The paper shows that increasing RNA Polymerase II levels enhances mRNA content and drives myofiber growth without needing additional nuclei.

This study identifies a multimodal transcriptional response in denervated skeletal muscle, revealing altered cholesterol homeostasis and its impact on myofiber size.

This study shows that TGFβ from cardiomyocytes programs fibroblast development and ECM environment to support cardiomyocyte maturation in the developing heart.

The paper identifies fibroblasts that adopt a myogenic program and fuse into muscle fibers at myotendinous junctions, contributing to junction formation through hybrid cell characteristics.

This study investigates the role of DOCK3 in skeletal muscle and Duchenne muscular dystrophy, finding that reducing DOCK3 improves dystrophic muscle histology while complete loss worsens muscle function.

The paper identifies myomerger as a critical protein required for myoblast fusion and demonstrates its role in inducing fusogenicity in non-fusogenic cells.