Identification of a fungal antibacterial endopeptidase that modulates immune responses
Silke Machata, Ute Bertsche, Franziska S. Hoffmann, Zaher M. Fattal, Franziska Kage, Michal Flak, Alexander Iliou, Falk Hillmann, Ferdinand von Eggeling, Hortense Slevogt, Axel A. Brakhage, Ilse Denise Jacobsen
The paper identifies a fungal endopeptidase, CwhA, that cleaves Gram-positive bacterial peptidoglycan, leading to bacterial lysis and immune stimulation.
EMBO Reports · Jul 4, 2025Peer-reviewedMicrobiology