Axel A. Brakhage

This paper shows that FloA, a flotillin in Aspergillus nidulans, is required for the internalization of PmaA during calcium stress, preventing calcium overload and promoting cell survival.

The paper shows human neutrophils release extracellular RNAs that modulate gene expression in Aspergillus fumigatus, independent of fungal argonaute proteins.

This study identifies Ypk2 as a multidrug susceptibility factor in C. glabrata by showing its role in modulating gene expression and drug resistance across antifungal classes.

This study shows the murine lung microbiome is dynamic and transient, with bacteria rapidly cleared by the immune system and not establishing stable colonization.

This study identifies SmpR as a transcription factor that coordinates secondary metabolism and antibacterial defense in A. fumigatus in response to bacterial signals.

The paper identifies a fungal endopeptidase, CwhA, that cleaves Gram-positive bacterial peptidoglycan, leading to bacterial lysis and immune stimulation.

The paper identifies a single amino acid change in fungal proteins that enables phagosomal membrane penetration, suggesting convergent evolution of virulence mechanisms across fungi.

This study shows that Aspergillus fumigatus infection in immunosuppressed mice disrupts lung microbiome balance, increasing anaerobic bacteria like Ligilactobacillus murinus, which can be internalized by epithelial cells.

The paper investigates the regulatory motifs in the cyp51A promoter of Aspergillus fumigatus that contribute to azole resistance, revealing iron-dependent and -independent roles of transcription factors.

This study uses dynamic optimization to analyze host-pathogen interactions in invasive aspergillosis, identifying key roles for epithelial cells and neutrophils in immune response and fungal virulence.

The paper identifies positively selected genes in Aspergillus fumigatus and related species, highlighting their roles in virulence, immune evasion, and adaptation.

This study identifies BasR as a regulatory node mediating bacterial-induced chromatin modifications and activation of secondary metabolism in fungi.